PRED-GPCR: GPCR recognition and family classification server
نویسندگان
چکیده
منابع مشابه
PRED-GPCR: GPCR recognition and family classification server
The vast cell-surface receptor family of G-protein coupled receptors (GPCRs) is the focus of both academic and pharmaceutical research due to their key role in cell physiology along with their amenability to drug intervention. As the data flow rate from the various genome and proteome projects continues to grow, so does the need for fast, automated and reliable screening for new members of the ...
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The G-protein coupled receptor (GPCR) superfamily fulfils various metabolic functions and interacts with a diverse range of ligands. There is a lack of sequence similarity between the six classes that comprise the GPCR superfamily. Moreover, most novel GPCRs found have low sequence similarity to other family members which makes it difficult to infer properties from related receptors. Many diffe...
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INTRODUCTION G protein-coupled receptors (GPCRs) were assumed to exist and function in the plasma membrane as monomeric proteins that became activated by binding of one agonist ligand to one receptor molecule (Bourne et al., 1990). However, although previous findings based on rather indirect measures such as radioligand binding had suggested a direct interaction of two receptors with each other...
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G-protein coupled receptors (GPCRs) constitute a broad class of cell-surface receptors, including several functionally distinct families, that play a key role in cellular signalling and regulation of basic physiological processes. GPCRs are the focus of a significant amount of current pharmaceutical research since they interact with more than 50% of prescription drugs, whereas they still compri...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2004
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkh431